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Technical Newsletter

24 September 2012

Preparation of Orally Disintegrating Tablet by Co-Spray Drying F-MELT® and Active Ingreditns

F-MELT® is a spray-dried excipient designed to manufacture Orally Disintegrating Tablet (ODT). ODT can easily be manufactured through direct compression by blending F-MELT® with active ingredient and lubricant. In certain cases where the formulation consists of cohesive fine particles, exhibits poor flowability and have high drug load, Co-Spray Dry (Co-SD) method is offered as a solution.


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08 June 2011

Oral Disintegration Tablets of Simvastatin with F-MELT®

This issue of Fuji's technical newsletter shows you the formulation of high quality Simvastatin ODT by simple blending of F-MELT®.

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16 February 2011

Formulating taste masked and high quality ODT of poorly water soluble drugs with F-MELT®

Are you looking for solutions to mask bitter taste and improve dissolution rates of poorly water soluble APIs in ODT formulations? In this application note, we present two successful case studies of Loratadine and Famotidine using Fuji’s F-MELT® ODT excipient system.

 

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08 April 2010

Discover new ways to improve ODT performance with Fuji F-MELT® system

An Oral Disintegrating Tablet (ODT) is defined as a solid dosage form that contains medicinal substances and disintegrates rapidly without water when placed on the tongue. Drug is released, dissolved or dispersed in the saliva and swallowed and absorbed across the gastro intestinal tract.

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01 April 2008

Effect of replacing Magnesium Stearate with Sodium Stearyl Fumarate on tableting of Fast-Disintegrating Oral Tablets with F-MELT®

In the March issue technical newsletter, we focused on achieving higher tablet hardness with pleasant mouth feel at good oral disintegrating (OD) times by addition of other common excipients. Although we achieved our objectives, the formulations were a bit complex for the formulators who want to keep the formulations simple.

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01 March 2008

F-MELT®-Directly Compressible Excipient System for Fast-Disintegrating Oral Tablets - II

In the February issue technical newsletter, we introduced F-MELT®, a proprietary excipient system for oral disintegrating tablets (ODT). ODT is a rapidly developing market and more and more technologies are coming to the fore front with distinct advantages. However, direct compression is still the preferred choice because it uses conventional equipment and materials while maintaining lower manufacturing costs.

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01 February 2008

Directly Compressible Excipient System for Fast-Disintegrating Oral Tablets

Fuji Chemical offers a simple alternative to the current fast-disintegrating technologies by offering a direct compression excipient that can be made into oral disintegrating tablets with standard tabletting equipment.



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