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Application Data

Nutraceutical Application

Sample formulations:
1. Vitamin B12 Formulation with F-MELT® Type C

Vitamin B12 is a water soluble vitamin which is required for proper red blood cell formation, neurological function and DNA synthesis. It is widely accepted as a dietary supplement and is consumed in microgram dosages. Oral Disintegrating Vitamin B12 nutraceutical tablets were prepared with F-MELT® type C.

This example shows a 500 μg Vitamin B12 preparation with F-MELT® Type C.

Vitamin B12 formulation with F-MELT® Type C (500 μg/tablet)

Batch Formula Batch Formula
Blending steps Blending steps
Tabletting Condition: Rotary tabletting machine (HT-AP18SS) at 15 rpm. Compression force of 4.8 - 5.2 KN
F-MELT® Vitamin B12 Characteristics
(10Φ 300 mg flat tablet)
F-MELT<sup>®</sup> Vitamin B 12 Characteristics
tabletes

2. CoQ10 Formulation with F-MELT® Type C

CoQ10 is a well established dietary supplement. This example shows successful tablet formulations of 350 mg and 1200 mg oral disintegrating tablets of CoQ10 at 17.5 to 60 mg load.

Smooth Water soluble CoQ10 (5% - 17.5 to 60 mg) OD Tablet Formulation

Batch Formula Batch Formula Tabletting Condition:
Rotary tabletting machine (HT-AP18SS) at
15 rpm


F-MELT CoQ10 tablet F-MELT® CoQ10 tablets φ10 mm 350 mg,
(CoQ10 - 17.5 mg)
F-MELT CoQ10 tablet F-MELT® CoQ10 tablets φ15 mm 1200 mg, (CoQ10 - 60 mg)
CoQ10: Molecular   weight: 863   Melting point: ca 48 ℃. Yellowish or orange colored crystal powder
Additional excipients like MCC and CMC and Talc were included to improve tablet properties
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